>Our 3rd Report to Stakeholders, 2011-12

Bringing Our Tests to Market

Partnerships and the PROOF Centre’s Development Pipeline

>Our 3rd Report to Stakeholders, 2011-12

Message from the Director

Never has there been a more urgent need for high-performance diagnostic tools to improve the treatment and quality of life of patients suffering from heart, lung and kidney failure. The burden is staggering; more than 60 million people have such organ failure in Canada and the USA alone. And the numbers continue to rise. The financial toll on our health system is just as immense.

At the PROOF Centre we are determined to help address this issue by bringing new tools in the form of novel blood tests to help clinicians better predict, diagnose and improve treatment of patients resulting in improved quality of life for patients and much lower costs to our health system. This past year we have been preparing our tests for the clinic. This means working with the best partners to help us develop the tests, identifying the appropriate platforms to bring them to the clinic and refining our blood tests to ensure the highest degrees of accuracy.

We have four tests ready to test in the clinic and several more on the way, making establishing a path to the market a priority. We continue to deepen our relationship with clinicians, health partners, patients and industry partners to begin clinical implementation so that patients with heart, lung and kidney failure can benefit from these new tests.

Bruce McManus signature

Bruce McManus
Director, PROOF Centre of Excellence

>Our 3rd Report to Stakeholders, 2011-12

Productivity & Growth

At the PROOF Centre, we have 14 blood tests in different stages of development for heart, lung and kidney failure. Every blood test we develop is created to meet a critical unmet social and clinical need with early engagement of clinicians, industry, government, and health stakeholders.

Two transplant tests are being evaluated in the clinic and two more tests will be ready for evaluation by family practice physicians in late 2013, empowering them to better manage their COPD and heart failure patients. We have refined our computationally-driven biomarker development process to ensure we are able to bring robust, clinically relevant markers into the diagnostic realm. We have also strengthened our relationship with clinical laboratories to help implement laboratory developed tests across Canada.

>Our 3rd Report to Stakeholders, 2011-12

New Plantings for the Future

On each step of our journey we work closely with clinicians and patients to ensure we understand their needs and achieve results that will improve patient care that are cost-efficient, and will be available for clinical use as fast as possible.

This ethos has led to several new and exciting partnerships, projects and programs at the PROOF Centre. Although just in their early stages, we know you’ll be hearing more about these developments in the near future as we close in on our goal – bringing the best of diagnostic tools to the clinics.

Financials

Statement of Financial Position

(Expressed in thousands of Canadian dollars)
March 31, 2012, with comparative figures for 2011

2012 2011
Assets:
Current assets:
Cash and cash equivalents 363 1,100
Short-term investments 4,971 7,523
Interest receivable - 13
Accounts receivable 867 61
Prepaid expenses and deposits 59 1,050
6,260 9,747
Capital assets, net of accumulated amortization of
$3,017(2011 - $2,168) 614 603
6,874 10,350
Liabilities and Net Assets (Deficiency):
Current liabilities:
Accounts payable and accrued liabilities 184 125
Deferred operating contributions (note 4) 6,178 9,300
Deferred capital contributions (note 5) 561 548
Net assets:    
Unrestricted (102) 322
Invested in capital assets 53 55
(49) 377
 
6,874 10,350

Statement of Operations

(Expressed in thousands of Canadian dollars)
Year ended March 31, 2012, with comparative figures for 2011

  2012 2011
Revenue    
Amortization of deferred operating contributions (note 4) 5,108 3,605
Amortization of deferred capital contributions (note 5) 799 823
Unrestricted contributions 2,526 974
Interest income 166 134
Gain (loss) on investments (35) 10
8,564 5,546
 
Expenses:
Core facilities (biomarkers program) 6,116 3,286
Materials and supplies 1,455 1,243
Equipment 210 127
Administrative salaries 404 346
Administrative operations 202 108
Hosting conferences 7 53
Attending conferences 169 153
Other knowledge dissemination 43 53
Market studies and business development 304 152
Intellectual property 79 218
Space improvements 1 1
  8,990 5,740
 
Deficiency of revenue over expenses (426) (194)

Statement of Changes in Net Assets (Deficiency)

(Expressed in thousands of Canadian dollars)
Year ended March 31, 2012, with comparative figures for 2011

Invested in capital assets Unrestricted 2012 2011
Balance, beginning of year 55 322 377 371
Deficiency of revenue over expenses (50) (376) (426) (194)
Transfer to invested in capital assets 48 (48) - -
 
Balance, end of year 53 (102) (49) 377

Statement of Cash Flows

(Expressed in thousands of Canadian dollars)
Year ended March 31, 2012, with comparative figures for 2011

2012 2011
Cash provided by (used in):
Operations:
Deficiency of revenue over expenses (426) (194)
Amortization of capital assets 849 873
Amortization of deferred capital contributions (799) (823)
Gain (loss) on investments 35 (10)
(341) (154)
Changes in non-cash operating working capital items:
Interest receivable 13 104
Accounts receivable (806) 4
Prepaid expenses and deposits 991 (488)
Accounts payable and accrued liabilities 59 (752)
Deferred operating contributions (3,122) (2,838)
(3,206) (4,124)
Investments:
Additions to capital assets (48) (48)
Additions (disposals) of short-term investments 2,517 (2,313)
2,469 (2,361)
Decrease in cash and cash equivalents (737) (6,485)
Cash and cash equivalents, beginning of year 1,100 7,585
Cash and cash equivalents, end of year 363 1,100
Supplemental information:
Cash received for interest 179 238
Non-cash transactions:
In-kind donation of capital assets 812 797

>Our 3rd Report to Stakeholders, 2011-12

Community of Partners

Funders

  • The Allergy, Genes and Environment Network (AllerGen)
  • Canadian Institutes of Health Research (CIHR IRSC)
  • Genome British Columbia
  • Networks of Centres of Excellence – Centres of Excellence for Commercialization and Research (CECR)
  • IO Informatics
  • MITACS
  • Pfizer Canada
  • Provincial Health Care Research Institute
  • Provincial Health Services Authority
  • Siemens
  • St. Paul’s Hospital Foundation
  • Transplant Research Foundation (TRF) of BC
  • University of British Columbia

Partners

  • Adiga Life Sciences
  • Alberta HEART
  • The Allergy, Genes and Environment Network (AllerGen)
  • BC Transplant (BCT)
  • Biomarkers Consortium
  • Canada India Network Society
  • Canadian Heart Failure Network (CHFN)
  • Canadian Institutes of Health Research (CIHR IRSC)
  • Collaboration for Outcomes Research and Evaluation (CORE)
  • Fasken Martineau
  • Fenwick & West
  • GlaxoSmithKline
  • HTG Molecular Diagnostics
  • Human Metabolome Project
  • Institute for Heart + Lung Health
  • IO Informatics
  • Luminex Corporation
  • MRM Proteomics
  • OriGene Technologies
  • Providence Health Care
  • Provincial Health Services Authority
  • Queensland Facility for Advanced Bioinformatics (QFAB)
  • Signals Design
  • Scripps Research Institute
  • UBC James Hogg Research Centre
  • University of British Columbia
  • UBC’s University-Industry Liaison Office
  • UVic Genome BC Proteomics Centre
  • Vancouver Coastal Health
  • Vancouver Coastal Health Research Institute